Reconstructing dynamics correlation network to simultaneously improve activity and stability of 2,3-butanediol dehydrogenase by design of distal interchain disulfide bonds
Zhongji Pu, Jiawen Cao, Wenhui Wu, Zhongdi Song, Lirong Yang, Jianping Wu, Haoran Yu
Topics & Concepts
Enzyme kineticsChemistrySubstrate (aquarium)Molecular dynamicsStereochemistryCatalytic cycleDirected evolutionEnzymeWild typeCatalysisDehydrogenaseMutantComputational chemistryActive siteCrystallographyBiochemistryBiologyEcologyGeneMicrobial Metabolic Engineering and BioproductionProtein Structure and DynamicsEnzyme Structure and Function