Design and synthesis of a NAD(P)H:quinone oxidoreductase 1-activatable photosensitiser for controlled photodynamic therapy
Evelyn Y. Xue, Fangyuan Kang, Yimin Zhou, Dennis K. P. Ng
Abstract
The utilisation of enzymes as stimuli can activate theranostic agents in a highly specific manner. We report herein a far-red-absorbing boron dipyrromethene-based photosensitiser that is responsive towards the cancer-associated human NAD(P)H:quinone oxidoreductase 1, enabling the controlled restoration of photodynamic activity for selective elimination of cancer cells.
Topics & Concepts
Photodynamic therapyNAD+ kinaseQuinoneChemistryOxidoreductaseCombinatorial chemistryStereochemistryNanotechnologyPhotochemistryMaterials scienceBiochemistryEnzymeOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry