A new cytotoxic indole alkaloid from the fungus <i>Penicillium polonicum</i> TY12
Xue-Yun Cai, Jia-Peng Wang, Yan Shu, Juntao Hu, Cheng-Tong Sun, Le Cai, Zhong‐Tao Ding
Abstract
A new dimeric monoterpene indole alkaloid polonidine A (1), along with five known compounds, cyclopenol (2), verrucosidin (3), fructigenine A (4), 3-O-methylviridicatin (5) and aurantiomides C (6), were isolated from Penicillium polonicum TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited moderate cytotoxic activities and moderate antibacterial activity against Bacillus subtilis with MIC of 4.0 μg/mL.
Topics & Concepts
AlkaloidIndole alkaloidBacillus subtilisFungusIndole testStereochemistryPenicilliumChemistryMonoterpeneCytotoxic T cellBiologyBotanyOrganic chemistryBacteriaFood scienceBiochemistryIn vitroGeneticsMicrobial Natural Products and BiosynthesisMycotoxins in Agriculture and FoodPlant-Microbe Interactions and Immunity