Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease
Ruben J. Colman, Abigail Samuels, Tomoyuki Mizuno, Nieko Punt, Alexander A. Vinks, Phillip Minar
Abstract
Lay Summary It is increasingly recognized that inconsistent biologic therapeutic response is related to pharmacokinetic variability (drug clearance) between patients. This study highlights a multidisciplinary effort to integrate a precision dosing dashboard within the electronic health record to individualize biologic exposure starting and during induction.
Topics & Concepts
DosingMedicineInflammatory bowel diseaseTherapeutic drug monitoringIntensive care medicineMultidisciplinary approachPharmacokineticsInflammatory Bowel DiseasesPrecision medicineDiseasePharmacologyInternal medicinePathologySociologySocial scienceBiosimilars and Bioanalytical MethodsInflammatory Bowel DiseasePharmaceutical studies and practices