A DNA-Schiff base functional nanopore sensing platform for the highly sensitive detection of Al<sup>3+</sup>and Zn<sup>2+</sup>ions
Shuailong Zhou, Jianhan Ye, Xiaohuan Zhao, Zihao Zhou, Yuanchen Dong, Qian Shi, Nannan Liu, Fen Wu
Abstract
, forming Schiff base-metal ion complexes at the four vertices of one face per nanocube unit. The steric hindrance effect of multiple Schiff bases and metal ion complexes leads to the blockage of internal structure and decrease of ion current in the GN. Owing to this signal amplification strategy, the detection limit of the target metal ion reaches a level of fM in the GN with a diameter of about 300 nm. In the future, this functional nanopore sensing platform is expected to realize highly sensitive detection for more biological metal ions by choosing appropriate receptors.
Topics & Concepts
NanoporeIonSchiff baseDNAChemistryBase (topology)NanotechnologyRadiochemistryMaterials scienceCrystallographyOrganic chemistryBiochemistryMathematical analysisMathematicsAdvanced biosensing and bioanalysis techniquesNanopore and Nanochannel Transport StudiesElectrochemical Analysis and Applications