Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice
Xiaofan Hu, Geng Xiang, Tianji Wang, Yubo Ma, Yang Zhang, Yabo Yan, Xiong Zhao, Zixiang Wu, Yafei Feng, Wei Lei
Abstract
: Diabetic osteopathy could be a chronic microvascular complication of T1DM. The impairment of type H vessels by NOX2-mediated endothelial oxidative stress might be an important contributor that can serve as a therapeutic target for T1DM-induced osteopathy.
Topics & Concepts
MedicineType 1 diabetesOxidative stressInternal medicineEndocrinologyAngiogenesisNADPH oxidaseDiabetes mellitusInsulinBone health and treatmentsBone Metabolism and DiseasesBone health and osteoporosis research