Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure
Keith A. Houck, Grace Patlewicz, Ann M. Richard, Antony Williams, Mahmoud Shobair, Marci G. Smeltz, Matthew S. Clifton, Barbara A. Wetmore, Alexander V. Medvedev, Sergei S. Makarov
Topics & Concepts
Pregnane X receptorNuclear receptorReceptorTransactivationToxicityTranscription factorEstrogen receptorEstrogen receptor alphaComputational biologyIn vitro toxicologyChemistryPharmacologyBiologyIn vitroBiochemistryGeneticsGeneOrganic chemistryBreast cancerCancerPer- and polyfluoroalkyl substances researchEffects and risks of endocrine disrupting chemicalsEstrogen and related hormone effects