T cell–mediated autoimmunity in immune thrombocytopenia
John R. Vrbensky, Ishac Nazy, Rumi Clare, Mark Larché, Donald M. Arnold
Abstract
Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti‐platelet autoantibodies, CD8 + T cells have been implicated as a mechanism of platelet destruction. The current evidence for the existence of platelet‐specific CD8 + T cells in ITP is inconclusive. The purpose of this review is to summarize the studies that investigated CD8 + T cells in ITP and to review the methods that have been used to detect autoreactive CD8 + T cells in other autoimmune diseases.
Topics & Concepts
Immune thrombocytopeniaImmunologyAutoimmunityAutoantibodyPlateletCD8MedicineImmune systemCytotoxic T cellT cellAutoimmune thrombocytopeniaBiologyAntibodyBiochemistryIn vitroPlatelet Disorders and TreatmentsAutoimmune Bullous Skin DiseasesBlood groups and transfusion