Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification
Yan Rong, Tony K. L. Kiang
Topics & Concepts
Mefenamic acidChemistryEnzymeNon-competitive inhibitionMetabolismSulfotransferaseRecombinant DNABiochemistrySubstrate (aquarium)MetaboliteEnzyme kineticsSulfationPharmacologyChromatographyBiologyActive siteEcologyGenePharmacogenetics and Drug MetabolismIon Transport and Channel RegulationDrug Transport and Resistance Mechanisms