G4-PROTAC: targeted degradation of a G-quadruplex binding protein
Kiran M. Patil, Danielle Chin, Hui Ling Seah, Qi Shi, Kah Wai Lim, Anh Tuân Phan
Abstract
G-quadruplex (G4) binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as a warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics.
Topics & Concepts
ProteolysisChemistryPlasma protein bindingProtein degradationDegradation (telecommunications)Computational biologyBiophysicsCell biologyBiochemistryBiologyComputer scienceTelecommunicationsEnzymeProtein Degradation and InhibitorsAdvanced biosensing and bioanalysis techniquesUbiquitin and proteasome pathways