A comparative study of the hypolipidemic effects and mechanisms of action of<i>Laminaria japonica</i>- and<i>Ascophyllum nodosum</i>-derived fucoidans in apolipoprotein E-deficient mice
Tian Liu, Xue Wang, Yanming Wang, F. F. Sui, Xueying Zhang, Haidi Liu, Dongyue Ma, Xiao-Xiao Liu, Shoudong Guo
Abstract
-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases.
Topics & Concepts
AscophyllumFucoidanLaminariaFucus vesiculosusBiologyBotanyAlgaeBiochemistryPolysaccharideSeaweed-derived Bioactive CompoundsBiochemical Acid Research StudiesAntioxidant Activity and Oxidative Stress