Dual modulation of blue-fluorescent carbon dots for simultaneous detection of topotecan and pantoprazole
Ashraf M. Mahmoud, Yahya S. Alqahtani, Mohamed M. El‐Wekil, Al‐Montaser Bellah H. Ali
Abstract
for PNT. Applied to spiked rabbit plasma samples, this method offers a new approach for evaluating the pharmacokinetic interaction between TOP and PNT. It enables the determination of all pharmacokinetic parameters of TOP before and after coadministration with PNT, providing essential insights into whether dose adjustments are necessary. This research not only contributes to the field of drug monitoring and interaction studies but also exemplifies the potential of B@NCDs in complex biological matrices, paving the way for further pharmacological and therapeutic applications.
Topics & Concepts
PantoprazoleTopotecanFluorescenceChemistryChromatographyPharmacologyMedicinePhysicsInternal medicineOpticsChemotherapyOmeprazoleCarbon and Quantum Dots ApplicationsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials