FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity
Jun Ren, Mingming Sun, Hao Zhou, Amir Ajoolabady, Yuan Zhou, Jun Tao, James R. Sowers, Yingmei Zhang
Abstract
The mitophagy receptor FUNDC1 interacts with FBXL2 to preserve mitochondrial Ca 2+ homeostasis and cardiac function in obesity.
Topics & Concepts
Function (biology)MitochondrionObesityBiologyNeuroscienceMedicineCell biologyEndocrinologyCardiovascular Function and Risk FactorsMitochondrial Function and PathologyPeroxisome Proliferator-Activated Receptors