Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)
Megan Greaves, Thomas O. Ronson, Guy C. Lloyd‐Jones, Feliu Maseras, Stephen Sproules, David J. Nelson
Abstract
-dppf)], which undergoes a halide abstraction reaction with alkyl halides and rapidly captures the alkyl radical that is formed. The rates of the reactions of [Ni(COD)(dppf)] with alkyl halides and the yields of prototypical nickel-catalyzed Kumada cross-coupling reactions of alkyl halides are shown to be significantly improved by the addition of free dppf ligand.
Topics & Concepts
HalideAlkylChemistryNickelCatalysisLigand (biochemistry)Medicinal chemistryOrganic chemistryBiochemistryReceptorCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms