Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior
Stephanie Rudolph, Chong Guo, Stan L. Pashkovski, Tomás Osorno, Winthrop F. Gillis, Jeremy M. Krauss, Hajnalka Nyitrai, Isabella Flaquer, M.A. El-Rifai, Sandeep Robert Datta, Wade G. Regehr
Abstract
Rs enable the cerebellum to control diverse behaviors not previously associated with the cerebellum in a sex-dependent manner. These insights may contribute to a better understanding of the mechanisms that underlie behavioral abnormalities in psychiatric and neurodevelopmental disorders that display a gender bias.
Topics & Concepts
GABAA receptorCerebellumNeuroscienceKnockout mouseBiologyProtein subunitReceptorPsychologyGeneticsGeneNeuroscience and Neuropharmacology ResearchHearing, Cochlea, Tinnitus, GeneticsNeuroinflammation and Neurodegeneration Mechanisms