CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions
Dan Su, Xu Feng, Medina Colic, Yunfei Wang, Chunchao Zhang, Chao Wang, Mengfan Tang, Traver Hart, Junjie Chen
Topics & Concepts
CRISPRBiologyCas9Genome editingCamptothecinDNA damageGeneDrug discoveryDNA repairGenetic screenDNASmall moleculeComputational biologyGeneticsSynthetic lethalityPARP inhibitorPhenotypePoly ADP ribose polymeraseBioinformaticsBiochemistryPolymeraseCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesDNA Repair Mechanisms