HDAC6-mediated Hsp90 deacetylation reduces aggregation and toxicity of the protein alpha-synuclein by regulating chaperone-mediated autophagy
Yunlan Du, Xiao Min Yang, Zezhi Li, Weidong Le, Yong Hao, Yeping Song, Fei Wang, Yangtai Guan
Topics & Concepts
HDAC6AutophagyAcetylationChemistryCell biologyAlpha-synucleinNeurodegenerationProtein aggregationHeat shock proteinHsp90LysosomeCrosstalkBiochemistryBiologyParkinson's diseaseHistone deacetylaseHistoneApoptosisEnzymeMedicinePhysicsPathologyDiseaseOpticsGeneHistone Deacetylase Inhibitors ResearchAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments