C−H Fluoromethoxylation of Arenes by Photoredox Catalysis
Giulia Bertoli, Ángel Manu Martínez, Jonas F. Goebel, Debora Belmonte, Nardana Sivendran, Lukas J. Gooßen
Abstract
Abstract Redox‐active N ‐(fluoromethoxy)benzotriazoles were made accessible from fluoroacetic acid and hydroxybenzotriazoles via electrodecarboxylative coupling. After alkylation, they become effective monofluoromethoxylation reagents, enabling the photocatalytic C−H functionalization of arenes. Thus, irradiation of 1‐(OCH 2 F)‐3‐Me‐6‐(CF 3 )benzotriazolium triflate with blue LED light in the presence of [Ru(bpy) 3 (PF 6 ) 2 ] promotes the synthesis of diversely functionalized aryl monofluoromethyl ethers. This method allows the late‐stage functionalization of biologically relevant structures without relying on ecologically problematic halofluorocarbons.