Synthesis of axially chiral diaryl ethers <i>via</i> NHC-catalyzed atroposelective esterification
Yingtao Wu, Xin Guan, Huaqiu Zhao, Mingrui Li, Tianlong Liang, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
Abstract
over-functionalization. This protocol features mild conditions, excellent enantioselectivity, broad substrate scope, and applicability to late-stage functionalization, and provides a modular platform for the synthesis of axially chiral diaryl ethers and their derivatives.
Topics & Concepts
CatalysisAxial symmetryChemistryCombinatorial chemistryStereochemistryOrganic chemistryPhysicsQuantum mechanicsAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis