Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow
Jesús Sanjosé‐Orduna, Rodrigo C. Silva, Fabian Raymenants, Bente Reus, Jannik Thaens, Kléber T. de Oliveira, Timothy Noël
Abstract
a HAT mechanism, and by acting as a benign, terminal oxidant. The key role of benzophenone in the operative reaction mechanism has also been revealed through a combination of experimental and computational studies.
Topics & Concepts
BenzophenoneAlkylationChemistryRadicalRegioselectivityCombinatorial chemistryAlkylPyridinePhotochemistryOrganic chemistryCatalysisInnovative Microfluidic and Catalytic Techniques InnovationRadical Photochemical ReactionsCatalytic C–H Functionalization Methods