Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines
Sian S. Berry, Simon Jones
Abstract
Chiral substituted pyrrolidines are key elements in various biologically active molecules and are therefore valuable synthetic targets. One traditional method towards enantiomerically pure compounds is the application of kinetic resolution. In this review, current KR methodology used in the synthesis of substituted pyrrolidines is surveyed, including enzymatic methods, cycloadditions and reduction of ketones.
Topics & Concepts
ChemistryKinetic resolutionCombinatorial chemistryResolution (logic)MoleculeEnantioselective synthesisComputational chemistryOrganic chemistryCatalysisComputer scienceArtificial intelligenceAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis