Targeted delivery of PROTAC-based prodrug activated by bond-cleavage bioorthogonal chemistry for microneedle-assisted cancer therapy
Jing Huang, Zhuo Yao, Bowen Li, Ping Yuan
Topics & Concepts
Bioorthogonal chemistryProdrugChemistryProtein degradationIn vivoDrug deliveryProteasomeUbiquitinBRD4BromodomainCombinatorial chemistryNanotechnologyBiochemistryEpigeneticsClick chemistryBiologyMaterials scienceOrganic chemistryGeneBiotechnologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis