Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles
Qiuyu Li, Yunchu Zhang, Yuye Zeng, Yujing Fan, Aijun Lin, Hequan Yao
Abstract
-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent enantio- and diastereoselectivities. This study is an important advance in the field of asymmetric carbonylation and enantioselective dearomatization reactions.
Topics & Concepts
CarbonylationChemistryEnantioselective synthesisStereocenterPalladiumCatalysisIndolineCombinatorial chemistryVicinalTandemOrganic chemistryStereochemistryCarbon monoxideComposite materialMaterials scienceCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis