Nitroreductase-responsive polymeric micelles based on 4-nitrobenzyl and AIE moieties for intracellular doxorubicin release
Xueyi Sun, Yaxuan Liang, Chengyan Wu, Quan Tang, Rui Liu, Zhong‐Lin Lu, Lan He
Abstract
An amphiphilic polymer<bold>TNP</bold>demonstrated the formation of a nitroreductase-responsive DOX delivery nanoplatform with high sensitivity and selectivity.
Topics & Concepts
NitroreductaseChemistryDoxorubicinMicelleAmphiphileIntracellularSelectivityCombinatorial chemistryBiophysicsPolymerBiochemistryCopolymerProdrugOrganic chemistryChemotherapyMedicineCatalysisBiologyAqueous solutionSurgeryAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery