Clinical Impact of Multi-omics profiling of extracellular vesicles in cancer Liquid Biopsy
Mrunal Kulkarni, Rishav Kar, Srestha Ghosh, Swarup Sonar, Divya Mirgh, I. Thekkemeppilly Sivakumar, Abhijit Nayak, Raman Muthusamy
Abstract
Extracellular vesicles (EVs) are the cell's secreted component. It is majorly classified into microvesicles, apoptotic bodies, and exosomes. Exosomes play a significant role in cancer development and progression. Its molecular signature (DNA, RNA, Proteins, lipids) has more priority in cancer profiling current decade. In cancer prevention, the most challenging part is early detection. EVs-based cancer screening develops a promising platform. Multi-Omics exosomes profiling-based liquid biopsy support early cancer detection more efficient way. This approach provides detailed molecular expression data (it may be inner cargos or surface express molecules). This article highlited multi-omic exosome profiling-based exosome theranostics applications in cancer, technical challenges, and improvisation for future improvement.