A CpxR-Regulated <i>zapD</i> Gene Involved in Biofilm Formation of Uropathogenic Proteus mirabilis
Honghan Chen, Chien-Che Chang, Yuhan Yuan, Shwu‐Jen Liaw
Abstract
Proteus mirabilis , a frequent uropathogen, forms extensive biofilms on catheters that are infamously difficult to treat. To explore the mechanisms of biofilm formation by P. mirabilis , we performed in vivo transposon mutagenesis. A mutant with impaired biofilm formation was isolated. The mutant was found to have Tn 5 inserted in the zapD gene, encoding an outer membrane protein of the putative type 1 secretion system ZapBCD.
Topics & Concepts
Proteus mirabilisBiologyTransposon mutagenesisBiofilmMicrobiologyMutantTransposable elementBacterial outer membraneMutagenesisSecretionGeneType VI secretion systemProteusBacteriaGeneticsVirulenceEscherichia coliBiochemistryUrinary Tract Infections ManagementProtist diversity and phylogenyEscherichia coli research studies