Cardiovascular decline in offspring during the perinatal period in an ovine model of fetal growth restriction
Charmaine R. Rock, Tegan A. White, Beth R. Piscopo, Amy E. Sutherland, Yen Pham, Emily J. Camm, Arvind Sehgal, Graeme R. Polglase, Stephanie Miller, Beth J. Allison
Abstract
Our findings provide novel insight into the potential mechanisms that program for cardiovascular dysfunction in growth-restricted neonates as our growth-restricted lambs exhibited a progressive decline in endothelium-dependent vasodilation in the femoral artery between birth and 4 wk of age. Subsequent analyses indicated that this reduction in vasodilatory capacity is likely to be mediated by the prostanoid pathway and prostanoids could be a potential target for therapeutic interventions for fetal growth restriction (FGR).
Topics & Concepts
OffspringMedicineInternal medicinePlacental insufficiencyFetusEndocrinologySubclinical infectionVasodilationIntrauterine growth restrictionCardiologyPhysiologyPregnancyBiologyPlacentaGeneticsBirth, Development, and HealthPregnancy and preeclampsia studiesNeonatal Respiratory Health Research