Copper‐Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T‐Cell Infiltration
Yuxiang Wang, Yawen Ding, Dan Yao, Hong Dong, Changwei Ji, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Abstract
Abstract Insufficient T‐cell infiltration seriously hinders the efficacy of tumor immunotherapy. Induction of immunogenic cell death (ICD) is a potentially feasible approach to increase T‐cell infiltration. Since ionizing radiation can only induce low‐level ICD, this study constructs Cu‐based nanoscale coordination polymers (Cu‐NCPs) with mixed‐valence (Cu + /Cu 2+ ), which can simultaneously and independently induce the generation of Cu + ‐triggered hydroxyl radicals and Cu 2+ ‐triggered GSH elimination, to synergize with radiation therapy for potent ICD induction. Markedly, this synergetic therapy remarkably enhances dendritic cell maturation and promotes antitumor CD8 + T‐cell infiltration, thereby potentiating the development of checkpoint blockade immunotherapies against primary and metastatic tumors.