Design, green one-pot synthesis and molecular docking study of novel N,N-bis(cyanoacetyl)hydrazines and bis-coumarins as effective inhibitors of DNA gyrase and topoisomerase IV
Nadia Hanafy Metwally, Sanaa O. Abdallah, Marwa Maher Abdel Mohsen
Topics & Concepts
DNA gyraseChemistryAntibacterial activityTopoisomeraseTopoisomerase IVMinimum inhibitory concentrationStereochemistryNorfloxacinDocking (animal)IC50Escherichia coliCombinatorial chemistryDNABiochemistryIn vitroAntibioticsBacteriaBiologyCiprofloxacinGeneNursingGeneticsMedicineSynthesis and biological activityCancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents