Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation
Chao Lü, Chune Ren, Tingting Yang, Yonghong Sun, Pengyun Qiao, Xue Han, Zhenhai Yu
Abstract
Our findings revealed that phosphorylation noncanonical FBP1 by PIM2 was a novel regulator of NF-κB pathway, and highlights PIM2 inhibitors as breast cancer therapeutics.
Topics & Concepts
PhosphorylationFructose 1,6-bisphosphataseCarcinogenesisChemistryNF-κBFructoseCell biologyCancer researchSignal transductionBiochemistryBiologyGeneCancer Mechanisms and TherapyPeptidase Inhibition and AnalysisMacrophage Migration Inhibitory Factor