New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria
Pietro Picconi, Charlotte K. Hind, Kazi S. Nahar, Shirin Jamshidi, Lucia Di Maggio, Naima Saeed, Bonnie Evans, Jessica Solomons, Matthew E. Wand, J. Mark Sutton, Khondaker Miraz Rahman
Abstract
of 3.16 ± 1.36 mg/L. This study provides a new chemical scaffold for developing novel broad-spectrum antibiotics which can help replenish the pipeline of antibiotics.
Topics & Concepts
Acinetobacter baumanniiAntibioticsDNA gyraseMicrobiologyPseudomonas aeruginosaChemistryMultiple drug resistanceBacteriaGram-negative bacteriaKlebsiella pneumoniaeAntibacterial activityBroad spectrumAntimicrobialMinimum inhibitory concentrationEnterobacterBiologyEscherichia coliCombinatorial chemistryBiochemistryGeneticsGeneSynthesis and pharmacology of benzodiazepine derivativesCancer therapeutics and mechanismsHIV/AIDS drug development and treatment