Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment
Shiwei Fu, Ajay Zheng, Lukun Wang, Jiuyan Chen, Bowen Zhao, Xiao Zhang, Victoria A A McKenzie, Zixin Yang, Roger M. Leblanc, Rajeev Prabhakar, Fuwu Zhang
Abstract
This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.
Topics & Concepts
DrugDrug deliveryAlbuminRedoxPharmacologyCancerMedicineTargeted drug deliveryChemistryCancer researchNanotechnologyInternal medicineMaterials scienceOrganic chemistryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsLipid Membrane Structure and Behavior