Improved vascular function and functional capacity following <scp>l</scp>-citrulline administration in patients with heart failure with preserved ejection fraction: a single-arm, open-label, prospective pilot study
Stephen M. Ratchford, Kanokwan Bunsawat, Jeremy K. Alpenglow, Jia Zhao, Josephine B. Wright, John Ryan, D. Walter Wray
Abstract
The current investigation has demonstrated that l-Cit administration may improve brachial artery endothelium-dependent vasodilation, upper and lower limb microvascular function, and physical capacity in patients with HFpEF, highlighting the potential therapeutic potential of interventions targeting the l-Arg-NO signaling cascade to improve outcomes in this patient group.
Topics & Concepts
MedicineBrachial arteryVasodilationEjection fractionHeart failureCardiologyInternal medicineEndotheliumOpen labelClinical trialBlood pressureCardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesCardiovascular Syncope and Autonomic Disorders