Pharmacological Insights into Janus Kinase Inhibition for the Treatment of Autoimmune Skin Diseases: A Literature Review
Mohammed Al Abadie, Zinah Sharara, Patrick Ball, Hana Morrissey
Abstract
The Janus kinase (JAK) family and signal transducer and activator of transcription (STAT) proteins play a central role in intracellular signaling pathways and mediate the effects of more than 50 cytokines and growth factors. JAK inhibitors act by selectively targeting receptor-associated kinases, thereby suppressing the transduction of pro-inflammatory signals. With increasing evidence supporting the therapeutic potential of targeted agents, both systemic and topical JAK inhibitors have been inv
Topics & Concepts
Janus kinaseJanusMedicineCancer researchImmunologyNanotechnologyMaterials scienceCytokineAutoimmune Bullous Skin DiseasesSkin and Cellular Biology ResearchCutaneous lymphoproliferative disorders research