Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation
Gholamhossein Sodeifian, Hamidreza Bagheri, Farnoush Masihpour, Negar Rajaei, Maryam Arbab Nooshabadi
Abstract
In order to micro and Nano sizing a drug via supercritical fluid technology , it is necessary to obtain its solubility in various ranges of pressures and temperatures. For this purpose, solubility of Niclosamide piperazine , in supercritical carbon dioxide (SC-CO 2 ) was measured by a new static method, for the first time. The measurements were performed at various circumstances, i.e. temperatures = 308, 318, 328 and 338 K and pressures = 12–27 MPa. The obtained results indicate that pressure significantly influences the solubility of Niclosamide piperazine , with a measured solubility ranging from 0.77 × 10 −7 to 13.60 × 10 −7 in mole fraction. To study theoretically the solubility of Niclosamide piperazine , the obtained results are modeled using nine semi-empirical equations i.e. Garlapati-Madras, Chrastil, Kumar-Johnston, Sodeifian et al. (models I-II), Bartle et al., Bian et al., Sung-Shim, Mendez-Santiago-Teja and Peng-Robinson EoS with van der Waals mixing rule. Among which the Bian et al., model and Peng-Robinson EoS showed the minimum AARD% of about 4.45 % (corresponding corrected Akaike Information Criterion is −704.09) and 7.54 % (corresponding corrected Akaike Information Criterion is −699.24), respectively. Finally, enthalpies for the binary mixture of Niclosamide piperazine -supercritical carbon dioxide binary system has been determined, for the first time.