Tunable protein crystal size distribution <i>via</i> continuous slug-flow crystallization with spatially varying temperature
Nicholas J. Mozdzierz, Moo Sun Hong, Yong-Kyu Lee, Moritz Benisch, Mo Jiang, Allan S. Myerson, Richard D. Braatz
Abstract
Under appropriate buffer and pH conditions, the magnitude and dispersion of the product protein crystals were reproducibly manipulated by controlling the spatial temperature along the tube in a continuous tubular crystallizer.
Topics & Concepts
CrystallizationDispersion (optics)Materials scienceProtein crystallizationCrystal (programming language)Flow (mathematics)Tube (container)Continuous flowSpatial dispersionCrystallographyChemical physicsChemical engineeringMechanicsChemistryOpticsComposite materialPhysicsComputer scienceProgramming languageEngineeringCrystallization and Solubility StudiesInnovative Microfluidic and Catalytic Techniques InnovationProtein purification and stability