Acute carbohydrate overfeeding: a redox model of insulin action and its impact on metabolic dysfunction in humans
Nawfal W. Istfan, Brooke Hasson, Caroline M. Apovian, Tova Meshulam, Liqun Yu, Wendy Anderson, Barbara E. Corkey
Abstract
Current principles assume that conversion of thermic energy to metabolically useful energy follows fixed rules. These principles ignore the possibility of variable proton uncoupling in mitochondria. Our study shows that the net balance of electron distribution between mitochondria and cytoplasm is influenced by insulin in a manner that reduces proton leakage during overfeeding. Characterization of the effects of insulin on redox balance is important for understanding obesity and insulin resistance.
Topics & Concepts
Insulin resistanceMitochondrionInsulinRedoxEndocrinologyInternal medicineCytoplasmChemistryBiochemistryBiologyMedicineOrganic chemistryDiet, Metabolism, and DiseaseAdipose Tissue and MetabolismDiet and metabolism studies