Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated <i>PHB2</i>
Xiaohong Xiang, Yunong Fu, Kun Zhao, Runchen Miao, Xing Zhang, Xiaohua Ma, Chang Liu, Nu Zhang, Kai Qu
Abstract
Our study established the role of PINT87aa as a novel biomarker and a key regulator of cellular senescence in HCC and identified PINT87aa as a potential therapeutic target for HCC.
Topics & Concepts
LAMP1BiologyCell biologyChromatin immunoprecipitationMolecular biologySenescenceCancer researchGene expressionBiochemistryGenePromoterEndosomeIntracellularCancer-related molecular mechanisms researchRNA modifications and cancerFOXO transcription factor regulation