Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis
Chen Zhou, Mingming Zhen, Meilan Yu, Xue Li, Tong Yu, Jingchao Liu, Wang Jia, Shuai Liu, Lei Li, Jie Li, Zihao Sun, Zhongpu Zhao, Xinyao Wang, Xiaoyan Zhang, Chunru Wang, Chunli Bai
Abstract
mice. Observably, GF-Ala improves hepatomegaly and hepatic lipid accumulation, reduces lipid peroxidation, and repairs abnormal mitochondria. Of note, we demonstrate that GF-Ala markedly inhibits the posttranslational degradation of apolipoprotein B100 (ApoB100) and boosts hepatocellular TG transport based on their superior antioxidant property. Together, we conclude that GF-Ala could potently ameliorate hepatic TG transport and maintain hepatic metabolic homeostasis without apparent toxicity, being beneficial for treatments of hepatic steatosis and other fatty liver diseases.