Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina
Li Xuan Tan, Colin J. Germer, Thushara Thamban, Nilsa La Cunza, Aparna Lakkaraju
Topics & Concepts
TFEBAutophagyCell biologyBiologyOptineurinSequestosome 1LysosomeRetinal pigment epitheliumPhagosomeAutophagosomeMechanistic target of rapamycinBECN1PI3K/AKT/mTOR pathwayNeurosciencePhagocytosisRetinaSignal transductionGeneticsBiochemistryEnzymeApoptosisAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismRetinal Diseases and Treatments