Drug-loaded polymeric nanoparticles: a review
Karine Cappuccio de Castro, Josiel Martins Costa, Maria Gabriela Nogueira Campos
Abstract
Polymeric nanoparticles are one of the most studied strategies in modern medicine for drug encapsulation. The researchers' main interest is a formulation capable of administering the medication in a controlled mode and specific site. In this context, stimulus-responsive nanoparticles are highlighted, as these systems can have long circulation times, achieve the disease site, and improve intracellular medication administration. Therefore, this review addressed trends in drug delivery mechanisms and the influence of internal and external stimulus sources on the stimulus-responsive nanocarriers. Moreover, conventional and emerging methods for the synthesis of polymeric nanoparticles were reviewed.