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Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler, Jordan Rossen, Mustafa Kocak, Jordan Bryan, Ranad Humeidi, D. D. Peck, Xiaoyun Wu, Andrew Tang, Vickie M. Wang, Samantha Bender, Evan Lemire, Rajiv Narayan, Philip Montgomery, Uri Ben‐David, Colin W. Garvie, Yejia Chen, Matthew G. Rees, Nicholas Lyons, James M. McFarland, Bang Wong, Li Wang, Nancy Dumont, Patrick J. O’Hearn, Eric Stefan, John G. Doench, Caitlin Harrington, Heidi Greulich, Matthew Meyerson, Francisca Vázquez, Aravind Subramanian, Jennifer A. Roth, Joshua A. Bittker, Jesse S. Boehm, Christopher C. Mader, Aviad Tsherniak, Todd R. Golub

2020Nature Cancer883 citationsDOIOpen Access PDF

Topics & Concepts

Drug repositioningRepurposingCell cultureCancer researchDrugBiologyPharmacologyCancer cellCancerMedicineComputational biologyGeneticsEcologyDrug Transport and Resistance MechanismsTrace Elements in HealthTuberculosis Research and Epidemiology
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