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PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H. Heidel, Tina M. Schnöder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph A. Schmid, Johanna Baumgartner, Stefan Freigang, Sabina Berezowska, Alessandro Rimessi, Georgia Konstantinidou

2020Nature Cell Biology30 citationsDOIOpen Access PDF

Topics & Concepts

KRASHypoxia (environmental)BiologyCancer researchGlycolysisCell biologyCell growthAdenocarcinomaApoptosisCancer cellLung cancerMitochondrionCancerChemistryInternal medicineBiochemistryMetabolismMutationGeneOxygenGeneticsMedicineOrganic chemistryMitochondrial Function and PathologyATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism
PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia | Litcius