Litcius/Paper detail

A cryptic pocket in CB1 drives peripheral and functional selectivity

Vipin Ashok Rangari, Evan S. O’Brien, Alexander S. Powers, Richard A. Slivicki, Zachariah Bertels, Kevin Appourchaux, Deniz Aydın, Nokomis Ramos‐Gonzalez, Juliet M. Mwirigi, Li Lin, Elizaveta Mangutov, Briana L. Sobecks, Yaseen Awad-Agbaria, Manoj B. Uphade, Jhoan Aguilar, Teja Peddada, Yuki Shiimura, Xi‐Ping Huang, Jakayla Folarin‐Hines, Maria Payne, Anirudh Kalathil, Balázs R. Varga, Brian K. Kobilka, Amynah Pradhan, Michael D. Cameron, Kaavya Krishna Kumar, Ron O. Dror, Robert W. Gereau, Susruta Majumdar

2025Nature35 citationsDOIOpen Access PDF

Topics & Concepts

AnalgesicCannabinoid receptorReceptorCannabinoidPharmacologyFunctional selectivityOpioidAgonistChronic painG protein-coupled receptorMedicineChemistryNeuroscienceBiologyInternal medicineCannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorPharmacological Receptor Mechanisms and Effects