Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death
Itziar Otano, Maite Álvarez, Luna Minute, María C. Ochoa, Itziar Miguéliz, Carmen Molina, Arantza Azpilikueta, Carlos E. de Andrea, Iñaki Etxeberría, Miguel F. Sanmamed, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Abstract
: The use of TNF blocking agents reduces oxidative stress, hyperpolarization of mitochondria, and the generation of DNA damage in CD8 T celss undergoing activation. The fact that TNF mediates AICD in human tumor-reactive CD8 T cells suggests that the use of TNF-blocking agents can be exploited in immunotherapy strategies.
Topics & Concepts
CD28Tumor necrosis factor alphaCytotoxic T cellCD8Cell biologyChemistryT cellCancer researchApoptosisMolecular biologyBiologyImmunologyAntigenImmune systemBiochemistryIn vitroImmune Cell Function and InteractionImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers