Facile synthesis of amides<i>via</i>acceptorless dehydrogenative coupling of aryl epoxides and amines
Yaoyu Liang, Jie Luo, David Milstein
Abstract
gas as the only byproduct. Control experiments indicate that amides are generated kinetically faster than side products, possibly because of the facile activation of epoxides by metal-ligand cooperation, as supported by the observation of a ruthenium-enolate species. No alcohol or free aldehyde are involved. A mechanism is proposed involving a dual role of the catalyst, which is responsible for the high yield and selectivity of the new reaction.
Topics & Concepts
ChemistryRutheniumYield (engineering)ArylAldehydeCombinatorial chemistryCatalysisLigand (biochemistry)Pincer movementAlcoholOrganic chemistrySelectivityMaterials scienceReceptorMetallurgyBiochemistryAlkylAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisChemical Synthesis and Reactions