Time-dependent interactions of blood platelets and cancer cells, accompanied by extramedullary hematopoiesis, lead to increased platelet activation and reactivity in a mouse orthotopic model of breast cancer – implications for pulmonary and liver metastasis
Hassan Kassassir, Kamil Karolczak, Karolina Siewiera, Dagmara Wójkowska, Marcin Braun, Cezary Watała
Abstract
.The primed circulating platelets became more sensitive to subthreshold stimuli at advanced stages of tumor development, and the formation of platelet-cancer cell aggregates increased with cancer progression. Our findings demonstrate that the age-associated progression of breast cancer cells is connected with increased platelet functioning, and that it can be manifested by the increased number of metastases and extramedullary hematopoiesis in a time-dependent-manner.
Topics & Concepts
PlateletHaematopoiesisBreast cancerReactivity (psychology)Cancer researchBlood cancerPlatelet activationMedicineCancerPulmonary cancerImmunologyInternal medicinePathologyBiologyStem cellCell biologyAlternative medicineInflammatory Biomarkers in Disease PrognosisImmune cells in cancerAdipokines, Inflammation, and Metabolic Diseases