Interruption of Capsular Polysaccharide Biosynthesis Gene <i>wbaZ</i> by Insertion Sequence IS <i>903B</i> Mediates Resistance to a Lytic Phage against ST11 K64 Carbapenem-Resistant Klebsiella pneumoniae
Xin Yin, Qingqing Fang, Zhiyong Zong
Abstract
by an insertion sequence-formed composite transposon. Our study demonstrates the capsular polysaccharide biosynthesis gene cluster as a major source of resistance to certain lytic phages in CRKP. This requires more studies to counter phage resistance. Our studies also highlight the critical role of insertion sequences in phage resistance.
Topics & Concepts
Lytic cycleKlebsiella pneumoniaeMicrobiologyPhage therapyAntimicrobialKlebsiellaMultiple drug resistanceBiologyVirologyGeneBacteriophageDrug resistanceEscherichia coliVirusGeneticsBacteriophages and microbial interactionsGenomics and Phylogenetic StudiesAntibiotic Resistance in Bacteria