SARS-CoV-2 infection downregulates myocardial ACE2 and potentiates cardiac inflammation in humans and hamsters
Anissa Viveiros, Ryan S. Noyce, Mahmoud Gheblawi, Daniele Colombo, Leanne M. Bilawchuk, Xavier Clemente‐Casares, David Marchant, Zamaneh Kassiri, Franca Del Nonno, David H. Evans, Gavin Y. Oudit
Abstract
Cardiac manifestations of COVID-19 in humans are mirrored in the SARS-CoV-2 hamster model, recapitulating myocardial damage, ACE2 downregulation, and a consistent pattern of immune cell infiltration independent of viral dose and variant. Therefore, the hamster model is a valid approach to study therapeutic strategies for COVID-19-related heart disease.
Topics & Concepts
HamsterDownregulation and upregulationCoronavirus disease 2019 (COVID-19)InflammationMesocricetusImmune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MedicineImmunology2019-20 coronavirus outbreakVirologyMyocarditisDiseaseBiologyInfectious disease (medical specialty)Internal medicineGeneBiochemistryOutbreakCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19