A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
Uday S. Ganapathy, Rubén González del Río, Mónica Cacho-Izquierdo, Fátima Ortega, Joël Lelièvre, David Barros-Aguirre, Marissa Lindman, Véronique Dartois, Martin Gengenbacher, Thomas Dick
Abstract
and was effective in a mouse lung infection model. Resistant mutant selection experiments showed a low frequency of resistance and confirmed leucyl-tRNA synthetase as the target. This work establishes the benzoxaborole EC/11770 as a novel preclinical candidate for the treatment of NTM lung disease and tuberculosis and validates leucyl-tRNA synthetase as an attractive target for the development of broad-spectrum anti-mycobacterials.
Topics & Concepts
AntimycobacterialNontuberculous mycobacteriaRepurposingBroad spectrumAntibioticsMycobacterium avium complexMedicineBiologyMicrobiologyPharmacologyVirologyTuberculosisMycobacteriumChemistryMycobacterium tuberculosisPathologyEcologyCombinatorial chemistryMycobacterium research and diagnosisTuberculosis Research and EpidemiologyRNA and protein synthesis mechanisms